The measurement is usually made by external ultrasound and occasionally by internal, invasive ultrasound catheters. Patient 2 had a followup study visit with carotid ultrasound 16. Comparison between automated and manual measurements of. Intimamedia thickness of carotid artery and aortic pulse. Carotid intimamedia thickness arteriosclerosis, thrombosis. We have developed dicombased software that measures cimt rapidly on. The atherosclerotic process occurs in the first 2 walls, resulting in a structural change in the early period as an increase in carotid intimamedia thickness cimt. The test measures the thickness of the inner two layers of the carotid arterythe intima and mediaand alerts physicians to any. The upper limit of normal for the mean carotid intimamedia thickness ranged from 0. The interpretation of ccimt values has been hampered by the absence of reference values, however. Genoa, italy, equipped with 712 mhz linear transducer and the automated software guided technique radiofrequencyquality intima media thickness in realtime qimt, esaote, maastricht, holland. Imt on the posterior wall is clearly distinguishable with carotid ultrasonography cus.
Carotid intimamedia thickness cimt has been shown to predict cardiovascular cv risk in multiple large studies. Manual measurements have been performed in most epidemiological studies, but, due to the introduction of new technologies, automated software has been increasingly used. Spectral doppler and automated softwareguided ultrasound. This can usually be achieved accurately in individuals over the age of 18 years. The video sequences are acquired from a bmode echographic scanner. Other segments carotid imt measurements are commonly obtained from the common carotid artery cca, as this vessel offers the easiest standardization due to its location, tubular shape, and parallel walls in most patients. Intima media thickness imt represents the thickness of the inner layers of a vessel, commonly the carotid artery. Ultrasound software tool measures carotid intimamedia. The carotid intimamedia thickness test cimt is a measure used to diagnose the extent of carotid atherosclerotic vascular disease. The relationship between carotid intimamedia thickness. In the 1980s, several studies concluded that bmode ultrasound imaging represent a.
Is intimamedia thickness a predictor for cardiovascular. Intervendor variability of carotid intimamedia thickness. Qimt software, using the rf radio frequency data processing signal in realtime, ensures high accuracy of a few m, making it the method of choice for early detection of atherosclerosis. This is the largest genomewide association study using consistent carotid intimamedia thickness cimt phenotyping to date.
Intimamedia thickness imt, also called intimal medial thickness, is a measurement of the thickness of artery walls, usually by external ultrasound, occasionally by internal, invasive ultrasound catheters, see ivus, to both detect the presence and to track the progression of atherosclerotic disease in humans. Common carotid artery intimamedia thickness ccimt is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease cvd. A spline model deformable template is fitted to the data to detect the artery boundaries and track them all along the video sequence. Carotid intimamedia thickness and plaque in cardiovascular.
The intima media thickness, also known as imt is the measurement of the actual combination of the intima and media layers of the carotid artery as measured by ultrasound duplex. Carotid intimamedial thickness measured on multiple ultrasound. Evaluation of a new carotid intimamedia thickness measurement by. The carotid intimamedia thickness was assessed in 8 subjects 64 men and 74 women aged 2079 years whose age and sex were homogeneously distributed. We aimed to investigate the change of cimt in prediabetes and type2 dm patients compared to subjects with normal glucose metabolism ngm. Carotid intimamedia thickness test cimt cedarssinai. We identified 2 novel loci for average of mean cimt values, 1 novel locus for average of maximum cimt values, and 1 for average of mean cimt valuesaverage of maximum carotid intimamedia thickness values. Evaluation of a new carotid intimamedia thickness measurement by bmode ultrasonography using an innovative measurement software, intimascope.
The aim of this study was to determine cimt ris in a cohort of 1012 healthy subjects from argentina. The effect of longterm homocysteinelowering on carotid. The automated softwareguided ultrasound assessment of. Intimamedia thickness intima media thickness imt, also called intimal medial thickness, is a measurement of the thickness of tunica intima and tunica media, the innermost two layers of the wall of an artery. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intimamedia thickness imt, pulse wave velocity pwv and. Common carotid artery cca intima media thickness imt is associated with coronary heart disease and can be measured on ultrasound images either by hand or with an automated edge detector. Carotid intimamedia thickness cimt as a proxy measure for atherosclerosis. Pdf measurement of the carotid intima, media and intima. The changes of individual carotid artery wall layer by aging. Carotid intimamedia thickness imt iac vascular testing.
Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intimamedia thickness. Extendedrelease niacin or ezetimibe and carotid intimamedia. Modelbased analysis of flowmediated dilation and intima. Currently, a new automated ultrasound software, based on radio frequency, called rfqimt technology,proved to be a useful method for assessing subclinical atherosclerosis with the measurement of the intima media thickness imt in carotid arteries. Figure 5 blandaltman plot comparing mean common carotid artery intima media thickness cimt values with reference laboratory novice reader. Carotid intimamedia thickness cimt is a relatively simple, noninvasive measure that uses ultrasound to detect the presence and extent of atherosclerosis in an artery. The measurement of carotid intima media thickness cimt has been used as a marker of arterial wall disease. At the heart of the system is computer software developed by nasas jet propulsion laboratory. A practical protocol to measure common carotid artery intimamedia.
Intima media thickness imt, also called intimal medial thickness, is a measurement of the thickness of artery walls, usually by external ultrasound, occasionally by internal, invasive ultrasound catheters, see ivus, to both detect the presence and to track the progression of atherosclerotic disease in humans. The morquio a cohort n 12 was 58% male and 42% female table 1. To assess the reliability of the automated radio frequency rfbased us measurement of carotid intimamedia thickness imt performed by rheumatologists and to evaluate the variability between this method and the conventional bmode us measurement of carotid imt in. Ultrasonographyderived carotid artery intimamedia thickness imt has been established as an early atherosclerotic imaging biomarker. Carotid intimamedia thickness values are significantly high. Multiexaminer reliability of automated radio frequencybased. Carotid ultrasonography was performed by a mylab 70 scanner esaote. To enhance diagnostic effectiveness, an ultrasound software tool has been developed that can measure the thickness of the intimamedia layers of the carotid artery, for assessing an asymptomatic patients risk of developing cardiovascular disease. Aortic intima media thickness measured by transabdominal ultrasound aimt is an intermediate phenotype of cardiovascular risk. Figure 5 blandaltman plot comparing mean common carotid artery intimamedia thickness cimt values with reference laboratory novice reader. Carotid intima media thickness imt is currently used to assess the relationship between progression of coronary and systemic atherosclerosis. Figure 1 shows the paper selection process for both analyses. Although software can perform more than a hundred measurements from each.
Currently, a new automated ultrasound software, based on radio frequency, called rfqimt technology,proved to be a useful method for assessing subclinical atherosclerosis with the measurement of the intimamedia thickness imt in carotid arteries. We present an endtoend system for the automatic measurement of flowmediated dilation fmd and intimamedia thickness imt for the assessment of the arterial function. Jan 10, 2016 carotid intimamedia thickness cimt is a relatively simple, noninvasive measure that uses ultrasound to detect the presence and extent of atherosclerosis in an artery. The aim of this study was to evaluate the presence of common carotid artery cca intima media thickness imt and circulation inflammation markers in patients with dd. Validation of a carotid intimamedia thickness border. Carotid intima media thickness as a surrogate measure for. To date, however, the possible impact of regular physical activity pa on this parameter has not been well. The measurement of carotid intimamedia thickness cimt is a valid method to quantify levels of atherosclerosis. A significant difference in intimamedia thickness measurement values was.
Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive control subjects and investigated the relations of these variables to atherosclerotic risk factors methods using bmode ultrasonography, we compared carotid artery intima media thickness and plaque. Abnormally increased carotid intima mediathickness and. Common carotid artery cca intimamedia thickness imt is associated with coronary heart disease and can be measured on ultrasound images either by hand or with an automated edge detector. We evaluated if ris for males and females and for left and right carotids were necessary. Multiexaminer reliability of automated radio frequency. However, one concern of imt measurement is intervendor variability. Reference intervals for common carotid intimamedia. Aortic intimamedia thickness measured by transabdominal ultrasound aimt is an intermediate phenotype of cardiovascular risk. A cardiorisk trained and experienced sonographer can.
The intimamedia thickness is considered a surrogate measure for atherosclerosis the thicker the imt, the worse it is considered. The manual image acquisition of carotid vessels was obtained before the automatic measurement of the intimamedia using qimt quality intima media thickness software, integrated into the instrument provided esaote mylab 30 cv. Extendedrelease niacin or ezetimibe and carotid intima. The artery wall contains 3 layers as tunica intima, tunica media and tunica adventitia. Manual measurements have been performed in most epidemiological studies, but, due to the introduction of new technologies. Measuring the thickness of the intima and media layers of the carotid artery wall carotid intimamedia thickness, or cimt is one way to assess the cardiovascular health of your patients. Common carotid artery intima media thickness ccimt is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease cvd. Associations of edgedetected and manualtraced common. Carotid intima media thickness cimt measured with ultrasound us is widely used as biomarker for arteriosclerosis and as surrogate endpoint in interventional studies to assess efficacy of drug therapies. To assess the reliability of the automated radio frequency rfbased us measurement of carotid intimamedia thickness imt performed by rheumatologists and to evaluate the variability between this method and the conventional bmode us measurement of carotid imt in ra patients. Measurement of the carotid intima, media and intimamedia thickness with ultrasound and new software article pdf available in korean circulation journal 358. Accordingly, several carotid intimamedia thickness measurements as well as plaque were related to established cardiovascular risk factors.
If a cimt shows increased thickness in the inner layers of the carotid artery, you may be at risk for cardiovascular disease. Intimamedia thickness imt definition imt is measured as the distance between lumenintima yellow line and mediaadventitia pink line interfaces. Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made mean or. The search strategy was carotid intima media or intima medial thickness or imt and folate or folic acid or folic for cimt papers and flowmediated dilation or endothelial function or fmd and folate or folic acid or folic for the fmd papers.
Details regarding the control and nonmorquio mps cohorts have been published 11, 12. Automated measurement of intimamedia thickness of carotid. We aimed to 1 investigate the reproducibility of aimt in a populationderived cohort of infants. Carotid intima media thickness reference intervals for a. The changes of individual carotid artery wall layer by. The cimt was determined as the average of three measurements in each common. Growing evidence indicates that depressive disorders dds are an important risk factor for atherosclerosis. Spectral doppler and automated softwareguided ultrasound assessment of bilateral common carotid intimamedia thickness in spondyloarthritis.
Intimamedia thickness imt, also called intimal medial thickness, is a measurement of the thickness of tunica intima and tunica media, the innermost two layers of the wall of an artery. The aim of this study was to evaluate the presence of common carotid artery cca intimamedia thickness imt and circulation inflammation markers in patients with dd. Intimamedia thickness imt is a marker of subclinical. Carotid intimamedia thickness imt was determined using automated software that evaluates imt by radiofrequency qimt. The angulation to calculate the common carotid of the artery was less than 60.
Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made. To enhance diagnostic effectiveness, an ultrasound software tool has been developed that can measure the thickness of the intima media layers of the carotid artery, for assessing an asymptomatic patients risk of developing cardiovascular disease. The upper limit of normal for the mean carotid intima media thickness ranged from 0. Carotid intimamedia thickness as measured with ultrasonography is an. Carotid intimamedia thickness and circulation markers of. An article from the ejournal of the esc council for cardiology practice vol. We performed this study to evaluate the feasibility and accuracy of the newly developed korean software ks for measurement of the carotid intimamedia thickness imt. Automated measurement of intima media thickness of carotid arteries in ultrasonography by computer software.
Strict us protocols are necessary to ensure reproducibility. Carotid intimamedia thickness imt iac vascular testing executive summary a. The imt reference value of a healthy person is approximately 0. Imt increases in atherosclerosis, making it a useful biomarker in hypertension, dyslipidemia, and the macrovascular complications of diabetes. The present study was conducted to compare the strengths of.
It is still unclear which layer intima or media is mainly involved in increased carotid intima. Intimamedia thickness imt has been proposed to be a. Comparison between carotid plaque and carotid intimamedia. Interest in carotid intimamedia thickness imt, as a tool to evaluate cardiovascular risk has been driven by studies that demonstrate a relationship between carotid imt and the incidence of.
Carotid intimamedia thickness values are significantly. Ultrasound software tool measures carotid intimamedia thickness. Intima media thickness imt is a marker of subclinical atherosclerosis asymptomatic organ damage and should be evaluated in every asymptomatic adult or hypertensive patient at moderate risk for cardiovascular disease. Reproducibility of aortic intimamedia thickness in infants. Carotid intima media thickness cimt increases in patients with adult type2 diabetes mellitus dm and is used for early detection of macrovascular complications. Measurement of the carotid intimamedia thickness enables arterial wall thickening to.
The test measures the thickness of the inner two layers of the carotid arterythe intima and mediaand alerts physicians to any thickening when patients are still asymptomatic. Measuring the thickness of the intima and media layers of the carotid artery wall carotid intima media thickness, or cimt is one way to assess the cardiovascular health of your patients. Qimt software, using the rf radio frequency data processing signal in realtime, ensures high accuracy of a few. Mti, a palm desert, ca company, has developed a diagnostic system to detect carotid atherosclerotic vascular disease in very early stages, when intima and media thickness is just a bit off baseline. Atherosclerosis, the underlying cause of coronary heart disease is characterized by an accumulation of lipids, white blood cells and cell debris in the inner layers of the. The carotid intima media thickness was assessed in 8 subjects 64 men and 74 women aged 2079 years whose age and sex were homogeneously distributed. Carotid intimamedia thickness and plaque in borderline. The measurement of carotid intimamedia thickness cimt has been used as a marker of arterial wall disease. Carotid intimamedia thickness in subjects with no cardiovascular.
In the 1980s, several studies concluded that bmode ultrasound imaging represent a useful approach for measurement of cimt 4,2731. Jan 27, 2015 the commercially available semiautomatic intimamedia thickness measurement software math 3. Measurements of carotid intimamedia thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Measurements of carotid intima media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Background and purpose in this study, we investigated intimamedia thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive control subjects and investigated the relations of these variables to atherosclerotic risk factors methods using bmode ultrasonography, we compared carotid artery intimamedia thickness and plaque. A carotid intima media thickness test cimt is used to determine the extent of plaque buildup in the walls of the arteries supplying blood to the head.
Reference intervals for common carotid intimamedia thickness. Cardiorisks sonographers are all trained to use our patented protocol using patented software. The association of cca imt with incident peripheral artery disease pad is poorly studied. Reference intervals ris of carotid intima media thickness cimt from large healthy population are still lacking in latin america. Carotid intima media thickness cimt as a proxy measure for atherosclerosis. Carotid intimamedia roughness and elasticity in hypertensive.
Carotid intimamedia thickness in the spanish population. Carotid intimamedia thickness cimt measured by bmode. Measurements of carotid intima media thickness in non. Pdf carotid intimamedia thickness in master athletes. Analysis of cardiovascular risk and carotid intimamedia. Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive con. Second, mean and standard deviation sd agerelated equations were. Intimamedia thickness definition of intimamedia thickness. We performed this study to evaluate the feasibility and accuracy of the newly developed korean software ks for measurement of the carotid intima media thickness imt.
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